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Separation of anticoagulant and fibrinolytic components from Agkistrodon acutus venom and its effect on blood coagulation system
[Abstract] Objective: To study the effect of thrombin-like and fibrinolytic enzymes isolated and purified from the same Agkistrodon acutus venom on the blood coagulation system. Methods: The thrombin-like and fibrinolytic enzymes were isolated and purified from Agkistrodon acutus venom by DEAE-Se...Read more -
Inhibitory effect of antitumor component I from Agkistrodon acutus venom on proliferation of human lung cancer A549 cells
[Abstract] Objective: To study the effect of Agkistrodon acutus venom tumor suppressor component I (AAVC-I) on the proliferation inhibition and apoptosis of human lung cancer A549 cells. Methods: The inhibition rates of AAVC-I at different concentrations on A549 cells for 24h and 48h were measure...Read more -
Inhibitory effect of antitumor component I of Agkistrodon halys venom on proliferation of human lung cancer A549 cells
[Abstract] Objective: To study the effect of Agkistrodon acutus venom tumor suppressor component I (AAVC-I) on the proliferation inhibition and apoptosis of human lung cancer A549 cells. Methods: The inhibition rates of AAVC-I at different concentrations on A549 cells for 24h and 48h were measure...Read more -
Study on thrombosis of anticoagulant components from Agkistrodon acutus venom
[Abstract] In this paper, the effects of the anticoagulant component of Agkistrodon acutus venom on thrombosis and thrombin time were studied. The results showed that this component could shorten thrombin time, and the thrombus formed after this component was coagulated. Soluble in 30% urea solut...Read more -
Study on Three-dimensional Fluorescence Spectra of Agkistrodon acutus Hemorrhagic Toxin Ⅲ
[Abstract] Snake venom contains a variety of metal proteins, which have different biological activities, such as anticoagulant factor (ACF), glycoside hydrolase (NADase), fibrinolytic component (FP) and haemorrhagic toxin. Studies on their biological activities, fluorescence spectra and structura...Read more -
Preparation and Study of IgY Antibodies Against the Common Base of Metallases from Agkistrodon halys Venom
[Abstract] [Objective] To prepare IgY antibody against the common motif of metalloproteinases from Agkistrodon acutus venom, and to study its effect on the activity of snake venom [Methods] By analyzing the common sequences of various metalloproteinases from Agkistrodon acutus venom, we designed ...Read more -
Study on the inhibitory effect of small molecular polypeptides from Agkistrodon acutus venom on A2780 cells
[Abstract] Objective To investigate the inhibitory effect of small molecular polypeptide fraction (K fraction) from Agkistrodon acutus venom on the proliferation of human ovarian cancer cell line A2780 and its mechanism. Methods MTT assay was used to detect the growth inhibition of K component on...Read more -
Separation of anticoagulant and fibrinolytic components from Agkistrodon halys venom and their effects on blood coagulation system
To study the effect of thrombin-like and fibrinolytic enzymes isolated and purified from the same Agkistrodon acutus venom on the blood coagulation system. Methods: The thrombin-like and fibrinolytic enzymes were isolated and purified from Agkistrodon acutus venom by DEAE-Sepharose CL-6B and Seph...Read more -
Research progress on pharmacological effects of agkistrodon halys venom
To discuss the pharmacological effects of Agkistrodon acutus venom. Methods: The latest research progress of chemical constituents, coagulation, antithrombotic effect, anti-tumor mechanism and other physiological activities of Agkistrodon acutus venom was reviewed. Results: The study shows that A...Read more -
Study on Thrombosis of Agglutinative Components from Agkistrodon halys Venom
The effect of the coagulating component of Agkistrodon acutus venom on thrombosis and thrombin time was studied. The results showed that the component could shorten the thrombin time and the thrombus formed after the component was coagulated. It can dissolve in 30% urea solution. The clotting tim...Read more -
How to treat retinal vein obstruction?
[Abstract] Objective To isolate and purify anticoagulant protein from Agkistrodon acutus venom in southern Anhui and observe its inhibitory effect on human vascular endothelial cells. Methods Human vascular endothelial cells EC-304 were cultured in vitro. CCK-8 colorimetry was used to determine t...Read more -
Experimental Study on the Effect of Anticoagulant Protein from Agkistrodon halys Venom on Human Vascular Endothelial Cell EC-304
[Abstract] Objective To isolate and purify anticoagulant protein from Agkistrodon acutus venom in southern Anhui and observe its inhibitory effect on human vascular endothelial cells. Methods Human vascular endothelial cells EC-304 were cultured in vitro. CCK-8 colorimetry was used to determine t...Read more